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Purpose: In cost-effectiveness analyses performed from the societal perspective, SF-6D, Health Utilities Index (HUI), and/or EuroQol-5D (EQ-5D) utilities are frequently included to calculate quality-adjusted life years. An increasing number of studies compare these utilities and report on the disagreement between these measures. The objective of our study was to review the published studies that compare the utilities of SF-6D, HUI3, and EQ-5D and investigate whether mean utilities differ systematically.
Methods: A Medline-search of the English literature was performed and references of the derived articles were reviewed. Studies were included if patients assessed their current health and if mean utilities were reported of at least two of the three measures SF-6D, HUI3, and EQ-5D. We used random effects models to generate pooled results.
Results: Seven studies published between 2000 and 2004 met the inclusion criteria. In all studies SF-6D was assessed, in 3 studies HUI3, and in 6 studies EQ-5D. In total 762 patients were included with various diseases (e.g., liver transplant, arthritis, cardiovascular disease). All three measures were completed by 249 patients, among the remaining patients 246 patients completed the SF-6D and HUI3 and 267 patients the SF-6D and EQ-5D. The mean age of the patients was was 57 years and 56% was male. The mean utilities across all measures and studies ranged from 0.43 to 0.70. The pooled difference in mean utilities was 0.02 (95%CI: - 0.001-0.05) between SF-6D and HUI3, 0.10 (95%CI: 0.07-0.12) between SF-6D and EQ-5D, and 0.05 (95%CI: 0.002-0.09) between HUI3 and EQ-5D.
Conclusion: In conclusion, the range of mean utilities in studies that compare the utility measures SF-6D, HUI3, and/or EQ-5D was small, even though they were performed across various diseases. The results demonstrated that mean utilities of the SF-6D and HUI3 did not differ systematically, whereas mean utilities of the EQ-5D were systematically lower.
See more of Poster Session - Public Health; Methodological Advances
See more of The 26th Annual Meeting of the Society for Medical Decision Making (October 17-20, 2004)