Purpose: Patients with prediabetes, both impaired glucose tolerance (IGT – 2 hour oral glucose tolerance test 140-199 mg/dl) and impaired fasting glucose (IFG – fasting plasma glucose 100-125 mg/dl), are at increased risk for cardiovascular disease as well as diabetes. The purpose of this study was to assess differences in risk profiles of IFG and IGT subjects. Methods: From January, 2005 to May, 2006, 733 volunteer subjects were screened for diabetes by oral glucose tolerance tests. Eight metabolic and cardiovascular risk factors, including blood pressure, gender-corrected waist circumference, gender-corrected HDL, LDL, triglycerides, albumin/creatinine ratio, alanine aminotransferase (ALT) and C-reactive protein (CRP), were included for analysis. Risk factor profiles of IGT, IFG and IGT+IFG were compared to normal glucose tolerant (NGT) subjects using multinomial logistic regression. Results: Of the 733 subjects, 34 were diabetic and excluded from analysis; 60 (8%) were IGT; 116(16%) IFG; 58 (8%) were IGT and IFG; 465 (68%) were normal glucose tolerant (NGT). Logistic regression identified ALT as greatest risk factors for IFG and IGT+IFG. Waist circumference was the most significant risk factor for IGT. With respect to the entire risk profile, all 3 groups were significantly different from NGT subjects (p < 0.001). Conclusions: IGT and IFG may present with different risk factors for metabolic and cardiovascular disease. Evaluation of glucose-intolerant individuals for CVD should include both fasting and 2-hour glucose levels.