Purpose: The purpose of this presentation is to explore the long-term psychological and quality of well-being effects of Hurricane Katrina on evacuees from the Gulf Coast and to identify factors that mediate these effects. Method: Beginning at the one year anniversary of the hurricane, telephone interviews with 102 evacuees who relocated to Louisville, KY were conducted. Results: At the time of the interview, 74 individuals still remained in Kentucky, 26 had returned to New Orleans, and 2 had returned to towns in Mississippi. These interviews consisted of measures of depression, anxiety, coping and post-traumatic stress disorder (PTSD). The health-related quality of life measure, Quality of Wellbeing Scale (QWB-SA), was administered. The results demonstrated significant and negative lasting effects on the evacuees' perceived well-being. Specifically, more than half of the sample met or exceeded criteria for PTSD; symptoms associated with anxiety and depression were present in most respondents, and quality of life, as measured by the QWB, was low. The overall mean QWB score was .61 (range, .11 to 1.0, SD = .19). High levels of anxiety, but not depression, PTSD, or quality of life, were significantly associated with the inability to find employment. Significantly higher rates of depression, anxiety and PTSD were found in persons who had returned to the Gulf Coast versus those who stayed in Louisville. The mean QWB scores for those who remained in Louisville were higher (.62), but not significantly so, than for those who returned to the Gulf Coast (.56). Higher levels of depression and anxiety and lower quality of well-being scores were evident in female versus male respondents. Evacuees who engaged in negative coping behaviors such as substance abuse, self-blame, denial, or disengagement fared worse in terms of depression, anxiety and quality of life. Conclusions: In conclusion, people whose lives were disrupted by Hurricane Katrina continue struggle with psychological wellbeing and quality of life more than a year after the waters have receded from the Gulf Coast. Data from this study can be useful in the development of risk prediction models that can aid providers in the early detection of individuals who will be vulnerable to the onset or recurrence of psychopathology post exposure.