Monday, October 19, 2009
Grand Ballroom, Salons 1 & 2 (Renaissance Hollywood Hotel)
Purposes: Previous studies have reported health utilities for migraine patients as generally measured between migraine attacks, but health utility data for within a migraine attack are unavailable. We evaluated health utilities among acute migraine patients experiencing different grades of headache severity.
Methods:
We examined data for 330 20-65 year-old adults, in good physical health, who had 1-6 moderate/severe migraine attacks per month in the 2 months prior to the screening visit. Data were collected from a multi-center, double-blind study of a treatment for acute migraine in the United States. The EuroQol (EQ-5D) system was used to measure generic health status at baseline and 24 hours post-treatment within an acute migraine attack and patients were also asked to rate their pain level at these time points (no, mild, moderate or severe pain). The D1 time-trade-off scoring algorithm for theResults: The study population was 88% female, and 78% white ethnicity, with 60% of subjects over age 40. The disutility of mild migraine pain was estimated to be 0.140 (95% CI: 0.0848, 0.1940), with a disutility for moderate migraine pain of 0.186 (95% CI: 0.1645, 0.2053) and for severe migraine pain of 0.493 (95% CI: 0.4100, 0.5654).
Conclusions:
The EuroQol (EQ-5D) instrument performed capably in distinguishing between different pain levels among acute migraine patients. These data can be of value in informing cost-utility policy analyses of migraine interventions.Candidate for the Lee B. Lusted Student Prize Competition