8 HEALTHCARE COSTS OF MEDICALLY-ATTENDED ADVERSE EFFECTS IN MEDICAID HIV PATIENTS ON ATAZANAVIR- AND DARUNAVIR-BASED ANTIRETROVIRAL THERAPY

Thursday, October 18, 2012
The Atrium (Hyatt Regency)
Poster Board # 8
Applied Health Economics (AHE)

Stephen Johnston, MA1, Timothy Juday, PhD2, Stephen Esker, PharmD2, Derek Espindle, MA3, Bong-Chul Chu, PhD4, Tony Hebden, PhD2 and Jonathan Uy, MD2, (1)Thomson Reuters, Washington, DC, (2)Bristol-Myers Squibb, Plainsboro, NJ, (3)Thomson Reuters, Cambridge, MA, (4)Thomson Reuters, Santa Barbara, CA
  

Purpose : Antiretroviral therapy (ART) adverse effects (AEs) can have a substantial impact on HIV patients' quality of life, healthcare resource utilization and adherence and persistence to ART. Atazanavir and darunavir are currently the only protease inhibitors preferred in first-line ART regimens in the Department of Health and Human Services (DHHS) antiretroviral treatment guidelines.  To date, atazanavir has not been compared to darunavir in either a clinical trial or the “real world” setting of routine care. This study is the first to compare the healthcare costs of medically-attended AEs in atazanavir- and darunavir-based ART among U.S. Medicaid patients receiving routine care.   

Method : Retrospective study using Medicaid administrative healthcare claims from 15 States. Subjects were HIV patients aged 18–64 years initiating atazanavir- or darunavir-based ART from 1/1/2003—7/1/2010, with continuous enrollment for 6 months before (baseline) and 6 months after (evaluation period) ART initiation, and ≥1 evaluation period medical claim. Outcomes were per-patient-per-month (PPPM) healthcare costs of medically-attended (ICD-9-CM-coded or treated) AEs during the evaluation period. Five AEs were chosen for study from those listed within the DHHS antiretroviral treatment guidelines as being specific to atazanavir and darunavir: gastrointestinal; lipid abnormalities; diabetes/hyperglycemia; rash; jaundice.  All-cause healthcare costs were also examined. Atazanavir and darunavir patients were propensity score matched (ratio=3:1, nearest neighbor with calipers technique) using demographic and clinical covariates. Multivariable models adjusted for covariates lacking post-match statistical balance.   

Result : Propensity-matched study sample included 1,848 atazanavir and 616 darunavir patients; mean age 41 years, 50% female, 69% black. Table displays unadjusted PPPM healthcare costs and adjusted PPPM healthcare cost differences (darunavir minus atazanavir). Jaundice occurred too infrequently to support multivariable modeling (11 instances in atazanavir, 1 in darunavir).   

Conclusion : Compared to atazanavir patients, patients treated with darunavir incurred higher adjusted healthcare costs for medically-attended AEs as well as higher all-cause healthcare costs, the difference being statistically significant in the latter case.

Atazanavir unadjusted

Darunavir unadjusted

Adjusted difference (Darunavir minus Atazanavir)

PPPM healthcare costs $, Mean [SD]

  Gastrointestinal

$38 [$387]

$73 [$382]

$43

p=0.132

  Lipid abnormalities

$14 [$544]

$0 [$4]

$3

p=0.879

  Diabetes/hyperglycemia

$28 [$396]

$27 [$297]

$13

p=0.693

  Rash

$96 [$1,253]

$62 [$518]

$0

p=0.760

  Jaundice

$6 [$80]

$5 [$25]

n/a

n/a

  All-cause healthcare

$3,879 [$6,635]

$5,354 [$8,127]

$1,086

p<0.001