5O-2 THE PERFORMANCE OF EQ-5D-5L AND VR-12 IN ASSESSING MENTAL HEALTH

Wednesday, October 26, 2016: 10:15 AM
Bayshore Ballroom Salon F, Lobby Level (Westin Bayshore Vancouver)

Fatima Al Sayah, PhD, Arto Ohinmaa, PhD and Jeffrey A Johnson, PhD, School of Public Health, University of Alberta, Edmonton, AB, Canada

Purpose:

   Our objective was to examine the performance of EQ-5D-5L (index score and the anxiety/ depression dimension), and the VR-12 version 2 (feeling downhearted/depressed item, mental health (MH) domain, and the Mental Composite Summary (MCS) score) in identifying individuals with depressive symptoms. 

Methods:

   Data were from an on-going cohort study of adults with type 2 diabetes in Alberta, Canada. The EQ-5D-5L index score and MCS were categorized into quintiles, and the MH domain into quartiles. Both EQ-5D-5L anxiety/depression dimension and VR-12 feeling downhearted/depressed item have five levels. Depressive symptoms were measured using the patient health questionnaire 8 items (PHQ), and were categorized into two severity levels: 1) any depressive symptoms (PHQ³10) vs. absent depressive symptoms (PHQ<10); 2) moderate-severe depressive symptoms (PHQ³15) vs. absent moderate-severe depressive symptoms (PHQ< 15). We calculated sensitivity (Sn), specificity (Sp), and area under receiver operator curve (AUROC) for each of the measures for the two levels of depressive symptoms.

Results:

   For any level of depressive symptoms: the levels that optimized performance of the measures were quintile 4 for EQ-5D-5L index score (Sn =83.4%; Sp =69.1%, AUROC=0.76), level 2 for the anxiety/depression dimension (Sn =91.7%; Sp =63.8%; AUROC=0.78), level 3 for the feeling downhearted/depressed item (Sn =72%; Sp =80.9%; AUROC=0.76), quartile 3 for the MH domain (Sn =85.4%; Sp =70.8%; AUROC=0.78), and quintile 4 for the MCS (Sn =90%; Sp =71.7%; AUROC=0.81). Overall AUROC were highest for MCS (0.90) and EQ-5D anxiety/depression (0.87).

   For moderate-severe depressive symptoms: the levels that optimized performance of the measures were quintile 4 for EQ-5D-5L index score (Sn =92.9%; Sp =64.3%; AUROC=0.79), level 3 for the anxiety/depression dimension (Sn =77.3%; Sp =88.6%; AUROC=0.83), level 3 for the feeling downhearted/depressed item (Sn =83.8%; Sp =76%; AUROC=0.80), quartile 3 for the MH domain (Sn =95.5%; Sp =65.4%; AUROC=0.80), and quintile 5 for the MCS (Sn =87.8%; Sp =86.3%; AUROC=0.87). Overall AUROC were highest for MCS (0.90) and EQ-5D anxiety/depression (0.90).

Conclusion:

   The EQ-5D anxiety/depression dimension performed similarly to the VR-12 MCS and slightly better than the VR-12 MH domain in identifying symptoms of depression in this sample of adults with type 2 diabetes.